Another weak jobs report has been released, with data on the September labor market. The report is late because of the shutdown — since when is jobs day a Tuesday? Weird! — but it shows that payrolls were up a scant 148,000 last month, though the unemployment rate ticked down a touch, to 7.2 percent from 7.3 percent (and not because people left the job market, which is why the jobless rate fell in earlier months).
If you're like most of the civilized world, you likely went to Google at some point today to find out what that rash is or pictures of that sex thing you heard about or the molecular weight of toffee or something. And you were greeted with this adorable animated doodle of the first parachute jump ever. Too bad it's wrong.
The number of DDoS (distributed denial-of-service) attacks that target weak spots in Web applications in addition to network services has risen during the past year and attackers are using increasingly sophisticated methods to bypass defenses, according to DDoS mitigation experts.
Researchers from Incapsula, a company that provides website security and DDoS protection services, recently mitigated a highly adaptive DDoS attack against one of its customers that went on for weeks and combined network-layer with application-layer -- Layer 7 -- attack techniques.
The target was a popular trading site that belongs to a prominent player in a highly competitive online industry and it was one of the most complex DDoS attacks Incapsula has ever had to deal with, the company's researchers said in a blog post.
The attack started soon after an ex-partner left the targeted company and the attackers appeared to have intimate knowledge of the weak spots in the target's infrastructure, suggesting that the two events might be connected, the researchers said.
The attack began with volumetric SYN floods designed to consume the target's bandwidth. It then progressed with HTTP floods against resource intensive pages, against special AJAX objects that supported some of the site's functions and against Incapsula's own resources.
The attackers then switched to using DDoS bots capable of storing session cookies in an attempt to bypass a mitigation technique that uses cookie tests to determine if requests come from real browsers. The ability to store cookies is usually a feature found in full-fledged browsers, not DDoS tools.
As Incapsula kept blocking the different attack methods, the attackers kept adapting and eventually they started flooding the website with requests sent by real browsers running on malware-infected computers.
"It looked like an abnormally high spike in human traffic," the Incapsula researchers said. "Still, even if the volumes and behavioral patterns were all wrong, every test we performed showed that these were real human visitors."
This real-browser attack was being launched from 20,000 computers infected with a variant of the PushDo malware, Incapsula later discovered. However, when the attack first started, the company had to temporarily use a last-resort mitigation technique that involved serving CAPTCHA challenges to users who matched a particular configuration.
The company learned that a PushDo variant capable of opening hidden browser instances on infected computers was behind the attack after a bug in the malware caused the rogue browser windows to be displayed on some computers. This led to users noticing Incapsula's block pages in those browsers and reaching out to the company with questions.
"This is the first time we've seen this technique used in a DDoS attack," said Marc Gaffan, co-founder of Incapsula.
The challenge with application-layer attacks is to distinguish human traffic from bot traffic, so DDoS mitigation providers often use browser fingerprinting techniques like cookie tests and JavaScript tests to determine if requests actually come from real browsers. Launching DDoS attacks from hidden, but real browser instances running on infected computers makes this type of detection very hard.
"We've been seeing more and more usage of application-layer attacks during the last year," Gaffan said, adding that evasion techniques are also adopted rapidly. "There's an ecosystem behind cybercrime tools and we predict that this method, which is new today, will become mainstream several months down the road," he said.
DDoS experts from Arbor Networks, another DDoS mitigation vendor, agree that there has been a rise in both the number and sophistication of Layer 7 attacks.
There have been some papers released this year about advanced Layer 7 attack techniques that can bypass DDoS mitigation capabilities and the bad guys are now catching on to them, said Marc Eisenbarth, manager of research for Arbor's Security Engineering and Response Team.
There's general chatter among attackers about bypassing detection and they're doing this by using headless browsers -- browser toolkits that don't have a user interface -- or by opening hidden browser instances, Eisenbarth said.
In addition, all malware that has man-in-the-browser functionality and is capable of injecting requests into existing browsing sessions can also be used for DDoS, he said.
Layer 7 attacks have become more targeted in nature with attackers routinely performing reconnaissance to find the weak spots in the applications they plan to attack. These weak spots can be resource-intensive libraries or scripts that result in a lot of database queries.
This behavior was observed during the attacks against U.S. banking websites a year ago when attackers decided to target the log-in services of those websites because they realized they could cause significant problems if users are prevented from logging in, Eisenbarth said. "We continued to see attackers launch those type of attacks and perform reconnaissance to find URLs that, when requested, may result in a lot of resource activity on the back end," he said.
More and more companies are putting together DDoS protection strategies, but they are more focused on network-layer attacks, Gaffan said. They look at things like redundancy or how much traffic their DDoS mitigation solution can take, but they should also consider whether they can resist application-layer attacks because these can be harder to defend against than volumetric attacks, he said.
With application-layer attacks there's an ongoing race between the bad guys coming up with evasion techniques and DDoS mitigation vendors or the targeted companies coming up with remedies until the next round, Gaffan said. Because of that, both companies and DDoS mitigation providers need to have a very dynamic strategy in place, he said.
"I think we will continue to see an evolution in the sophistication of application-layer attacks and we will see more and more of them," Gaffan said. They won't replace network-layer attacks, but will be used in combination with them, he said.
Having Layer 7 visibility is very important and companies should consider technologies that can provide that, Eisenbarth said. In addition to that, they should perform security audits and performance tests for their Web applications to see what kind of damage an attacker could do to them, he said.
Lucian Constantin, IDG News Service Reporter, IDG News Service, IDG News Service
Parisians and tourists sit at a cafe along the Seine River. The mayor of Paris recently close down a major highway along the river to open it up for pedestrians. Some drivers however aren't pleased with the traffic diversion.
Christophe Morin /Landov
In a daring gamble, the mayor of Paris recently shut off a major vehicle thoroughfare through the city, the highway along the Seine River.
The move is part of his plan to reduce traffic in the city. Parisians and tourists were delighted by the new space this summer, but many wonder if it'll be such a hot idea during the cold winter months.
Away from the busy street, next to the Pont Alexandre III Bridge that spans the Seine River, a new recreation and leisure area called Les Berges, or the banks, is set up for pedestrians. The area was once filled with cars speeding by, but now it's a place to take a stroll, ride a bike or just sit and hang out.
And hanging out is exactly what people are doing down on the berges on a recent Indian summer day. The noise of the traffic on the streets above is now replaced with other sounds, like a speedboat cutting through the waters.
There are new sights as well, like close-up views of the ornate sculpture on the sides of the bridges. Children frolic on a new playground, where a wall has been fitted with ropes and footholds for rock climbing.
Further on there's shuffleboard and chess, and wooden decks covered with plants and lounge chairs. There's even a couple of shipping containers with glass fronts that have been comfily furnished. You can rent a few hours in them to lounge around with your friends, undisturbed. Xavier Janc is head of the Berges project at Paris City Hall. He says it's designed to give Parisians what they want: nature, culture and sport.
"But most of all we wanted to get rid of this urban highway that marred the historic heart of the city," Janc says. "We wanted to give the river back to people who love Paris."
Everyone seems happy to be here, like Brigitte Loir, who was visiting the berges for the first time. She thinks the project is a very good idea.
"I'm very happy because since a few years, there are less and less cars in Paris, and it's beautiful," Loir says.
Though kicked back in a chaise lounge chair, sipping a drink at one of the new riverbank cafes, medical student Daniel Secnasie says he is less excited about the project.
"Yeah, it's a good idea for two months a year, he says, but the rest of the time, when it's cold and deserted, it's just forcing more traffic onto the streets above," Secnasie says.
That's exactly the problem, says Jerome Dubus, with the French business organization Medef. The pleasant pedestrian walk has made it much harder to get through the city in a car, he says.
"It's very difficult now to have economic growth in Paris because of traffic," Dubus says. "It's more expensive for all people now, because we made more time, and time is money."
Dubus says the berges project will hurt delivery businesses and small services like plumbers and electricians, and will increase overall congestion. The mile-and-a-half stretch of highway that's been closed off carried about 2,000 cars an hour during peak times. Dubus says now those cars will be forced up into the tiny streets of the left bank. He believes the mayor will have to cancel the project when he sees the results of a study his organization is carrying out with the Paris chamber of commerce.
Back at city hall, Janc says reversibility is one of the main pillars of the project, but he doesn't think it will be necessary. He says the traffic problems haven't been nearly as bad as anticipated.
Janc also says they have a few surprises up their sleeve for this winter to attract people to the river. Those cozy shipping containers, they'll be heated for anyone who wants to hang out on the Seine, in the rain, in the middle of January.
2 online science video pioneers combine to form new iBiology.org
PUBLIC RELEASE DATE:
22-Oct-2013
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Contact: John Fleischman jfleischman@ascb.org 513-706-0212 American Society for Cell Biology
SAN FRANCISCO, CAOctober 21, 2013Two pioneering online biology video sites, iBioSeminars and iBioMagazine, have merged to create iBiology.org, a new website with even more to offer the biology community. Following the model of its predecessors, iBiology.org will continue to provide videos by world-class biologists for free.
The new site aims to appeal to a broad audience, says iBiology Director Sarah Goodwin PhD, including the scientists, graduate students, and biology majors who avidly follow the research talks on iBioSeminars, as well as the viewers who enjoy the short discovery talks and scientist profiles on iBioMagazine. The newly merged site will also offer an exciting new stream of content in an "iBioEducation" section. iBioEducation features two microscopy courses, a completely new lecture series, including a talk by the 2013 Nobel Prize winner in Medicine, Randy Schekman, and short video clips excerpted from our seminar series. There are also numerous assessments and educator resources, which are free to registered educators.
iBiology was created to take modern biology anywhere in the world where there is a computer or smart phone in the hands of someone curious about the science of life. The iBiology collection currently features over 300 seminars and short talks, spanning 11 different areas of biology. To date, the iBioSeminars and iBioMagazine sites have had 1.4 million views, with an audience spread throughout 180 countries, and over 15,000 people subscribe to the iBiology newsletter, YouTube channel or follow on social media. Clearly many people are still curious about biology!
iBiology.org is based at UCSF with administrative support from the American Society for Cell Biology. The project is funded by the National Science Foundation, the National Institutes of General Medical Sciences of the NIH, and the Howard Hughes Medical Institute.
Here is a sampler of iBiology.org:
###
For further information, contact John Fleischman, ASCB Senior Science Writer, jfleischman@ascb.org, 513-706-0212.
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2 online science video pioneers combine to form new iBiology.org
PUBLIC RELEASE DATE:
22-Oct-2013
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Contact: John Fleischman jfleischman@ascb.org 513-706-0212 American Society for Cell Biology
SAN FRANCISCO, CAOctober 21, 2013Two pioneering online biology video sites, iBioSeminars and iBioMagazine, have merged to create iBiology.org, a new website with even more to offer the biology community. Following the model of its predecessors, iBiology.org will continue to provide videos by world-class biologists for free.
The new site aims to appeal to a broad audience, says iBiology Director Sarah Goodwin PhD, including the scientists, graduate students, and biology majors who avidly follow the research talks on iBioSeminars, as well as the viewers who enjoy the short discovery talks and scientist profiles on iBioMagazine. The newly merged site will also offer an exciting new stream of content in an "iBioEducation" section. iBioEducation features two microscopy courses, a completely new lecture series, including a talk by the 2013 Nobel Prize winner in Medicine, Randy Schekman, and short video clips excerpted from our seminar series. There are also numerous assessments and educator resources, which are free to registered educators.
iBiology was created to take modern biology anywhere in the world where there is a computer or smart phone in the hands of someone curious about the science of life. The iBiology collection currently features over 300 seminars and short talks, spanning 11 different areas of biology. To date, the iBioSeminars and iBioMagazine sites have had 1.4 million views, with an audience spread throughout 180 countries, and over 15,000 people subscribe to the iBiology newsletter, YouTube channel or follow on social media. Clearly many people are still curious about biology!
iBiology.org is based at UCSF with administrative support from the American Society for Cell Biology. The project is funded by the National Science Foundation, the National Institutes of General Medical Sciences of the NIH, and the Howard Hughes Medical Institute.
Here is a sampler of iBiology.org:
###
For further information, contact John Fleischman, ASCB Senior Science Writer, jfleischman@ascb.org, 513-706-0212.
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Share
]
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Nokia debuts a 6-inch Windows Phone with 20MP camera, along with its first Windows RT tablet
This morning at Nokia World in Abu Dhabi, UAE, the Finnish manufacturer has taken the wraps off some of its biggest Windows and Windows Phone devices yet. At the high end there's the Lumia 1520, a 6-inch Windows Phone 8 device with a 1080p display, Snapdragon 800 CPU and a 20-megapixel PureView camera. There's also the mid-range Lumia 1320, which aims to provide a big-screen experience at a more affordable $350 price point. And finally Nokia's Lumia 2520 is the company's first Windows RT tablet, with a 10.1-inch 1080p display inside a thin, colorful chassis.
The Windows Phone Central team are live on the ground in Abu Dhabi, and they've got extensive hands-on coverage of all Nokia's new toys. So hit up the links below to learn more about all the latest devices. And we're far from done with major mobile tech announcements for the day — multi-platform readers will want to check our sibling site iMore later today for full coverage of Apple's iPad announcements from San Francisco.
Nike Snowboarding’s Never Not Part 2 focuses on the places and faces of snowboarding. A lot of work goes into a street mission, or a backcountry adventure. In this video, Nike gives us an in-depth look at what their riders go through on a daily basis. Enjoy the shots and the wisdom of Gigi Ruf, Nicolas Muller, Justin Bennee, Halldor Helgason, Austin Smith, Louie Vito, Sage Kotsenburg, Jed Anderson, Manuel Diaz, Gjermund Braten, Spencer Obrien, Jess Kimura, Danny Kass, Ethan Morgan, and Peetu Piiroinen.
New York Giants' Peyton Hillis (44) rushes during the second half of an NFL football game against the Minnesota Vikings Monday, Oct. 21, 2013 in East Rutherford, N.J. (AP Photo/Peter Morgan)
New York Giants' Peyton Hillis (44) rushes during the second half of an NFL football game against the Minnesota Vikings Monday, Oct. 21, 2013 in East Rutherford, N.J. (AP Photo/Peter Morgan)
Minnesota Vikings running back Adrian Peterson (28) breaks a tackle by New York Giants' Jon Beason (52) as Jerome Felton (42) trails the play during the second half of an NFL football game Monday, Oct. 21, 2013 in East Rutherford, N.J. (AP Photo/Bill Kostroun)
Minnesota Vikings running back Adrian Peterson (28) stiff-arms New York Giants' Jon Beason (52) during the second half of an NFL football game Monday, Oct. 21, 2013 in East Rutherford, N.J. (AP Photo/Bill Kostroun)
New York Giants kicker Josh Brown (3) kicks a field goal during the second half of an NFL football game against the Minnesota Vikings Monday, Oct. 21, 2013 in East Rutherford, N.J. (AP Photo/Bill Kostroun)
EAST RUTHERFORD, N.J. (AP) — The New York Giants got their first win of the season Monday night by holding Adrian Peterson in check and converting Minnesota mistakes into a 23-7 victory.
The Giants began the season with six losses in which they were the team turning over the ball and showing little penchant for playing defense. But against the Vikings (1-5), they were efficient enough, if not overwhelming, and had three takeaways.
Peterson, the league's MVP last season, was held to 28 yards rushing five days after his 2-year-old son was buried in South Dakota. The man accused in the death was indicted on second-degree murder and manslaughter charges Monday.
Peterson was not aided by a rusty Josh Freeman, making his debut as Vikings quarterback.
Josh Brown kicked three field goals, Rueben Randle caught a 24-yard TD pass and Peyton Hills ran for a TD for New York (1-6).
Detroit Tigers skipper Jim Leyland told reporters: "I'm going to be 69 years old [on Dec. 15]. I'm not ashamed of that. I'm proud of it. The fuel's getting a little low."
The news comes two days after the Tigers were eliminated by the Boston Red Sox in Game 6 of the American League championship series.
Leyland, who said he'll stay with the Tigers in a job yet to be determined, steps down after eight seasons leading Detroit. Over his career, as NPR's Mike Pesca tells our Newscast Desk, Leyland "won three manager of the year awards, three pennants, more than 1,700 games and a World Series [when he managed the Florida Marlins in 1997]."
The World Series, between the Red Sox and National League champion St. Louis Cardinals, starts Wednesday night in Boston. Over the weekend, Eyder posted on "5 Things To Know About The World Series."
NPR's Mike Pesca on Jim Leyland's decision to step down
WASHINGTON (AP) — President Barack Obama called French President Francois Hollande on Monday to discuss France's anger over reported aggressive surveillance tactics by the National Security Agency.
The call came after a French newspaper said the NSA swept up 70.3 million French phone records in a 30-day period. France summoned the U.S. ambassador to explain and called the practice "totally unacceptable."
The White House says some recent disclosures about the NSA have been distorted but that some raise legitimate questions for U.S. allies about how America's intelligence capabilities are used.
Obama told the French president that the U.S. was reviewing its intelligence-gathering to ensure a balance between security and privacy.
The French president's office said in a statement that Hollande told Obama he strongly condemned the practices and found them unacceptable between allies. Hollande also asked Obama to specify all the information that former NSA systems analyst Edward Snowden may possess. Documents leaked by Snowden have been behind a series of revelations about NSA surveillance programs.
The White House said both presidents agreed they should continue diplomatic discussions about the issue.
A Norfolk Southern Railroad train pulls transport cars full of coal near Goodfield, Ill., on Oct. 9, 2012. The United States cut its energy-related carbon dioxide pollution by 3.8 percent in 2012, the second biggest drop since 1990, the Department of Energy said Monday, Oct. 21, 2013. Energy Department economist Perry Lindstrom said carbon pollution reduction is due to warm winter weather, more efficient cars because of new mileage requirements and an ongoing shift from coal-power to natural gas to produce electricity. (AP Photo/Seth Perlman)
A Norfolk Southern Railroad train pulls transport cars full of coal near Goodfield, Ill., on Oct. 9, 2012. The United States cut its energy-related carbon dioxide pollution by 3.8 percent in 2012, the second biggest drop since 1990, the Department of Energy said Monday, Oct. 21, 2013. Energy Department economist Perry Lindstrom said carbon pollution reduction is due to warm winter weather, more efficient cars because of new mileage requirements and an ongoing shift from coal-power to natural gas to produce electricity. (AP Photo/Seth Perlman)
WASHINGTON (AP) — The United States cut its energy-related carbon dioxide pollution by 3.8 percent last year, the second biggest drop since 1990, the Department of Energy said Monday.
The only recent year with a bigger percentage drop was in 2009, when America was in a large recession. American cars and factories spewed 5.83 billion tons of carbon dioxide in 2012, down from 6.06 billion in 2011. It is the lowest level for U.S. emissions since 1994. Carbon dioxide is the chief man-made global warming gas.
Energy Department economist Perry Lindstrom said carbon pollution reduction is due to warm winter weather, more efficient cars because of new mileage requirements and an ongoing shift from coal-power to natural gas to produce electricity.
The coal shift is a big factor as is a sluggish economic recovery, said Jay Apt, director of the Carnegie Mellon Electricity Industry Center. He said in 1994 coal provided 52 percent of the U.S. power and now it is down to 37 percent. Burning coal produces far more carbon dioxide than burning natural gas.
Some past cuts in carbon pollution were mostly due to economic factors, such as the 7.1 percent drop in 2009, Lindstrom said. But this drop happened while the U.S. economy was growing 2.8 percent, as reflected by the gross domestic product, and its energy use was dropping by more than 2 percent.
Economists measure energy efficiency and how real reductions are in carbon pollution, by calculating carbon dioxide emissions per unit of GDP. And from 2011 to 2012, the United States carbon pollution per GDP dropped by a record 6.5 percent, Lindstrom said.
That shows this drop was clearly not due to a recession, Lindstrom said.
In 2012, America spewed more than 368,000 pounds of carbon dioxide per second.
"This latest drop in energy-related carbon emissions is reason for cautious optimism that we're already starting to move in the right direction," said Pennsylvania State University climate scientist Michael Mann. "But this alone will not lead us toward the dramatic carbon reductions necessary to avoid dangerous climate change."
The world is heading in the opposite direction. In 2011, the world carbon dioxide emissions jumped 3 percent, because of a large increase by China, the No. 1 carbon polluting country. The U.S. is No. 2 in carbon emissions.
___
Online:
The Department of Energy: http://www.eia.gov/environment/emissions/carbon/
___
Seth Borenstein can be followed at http://twitter.com/borenbears
Controlling the triggers of age-related inflammation could extend 'healthspan'
PUBLIC RELEASE DATE:
21-Oct-2013
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Contact: Karen Peart karen.peart@yale.edu 203-432-1326 Yale University
Inflammation is the common denominator of many chronic age-related diseases such as arthritis, gout, Alzheimer's, and diabetes. But according to a Yale School of Medicine study, even in the absence of a disease, inflammation can lead to serious loss of function throughout the body, reducing healthspan that portion of our lives spent relatively free of serious illness and disability.
Published as the cover article in the October issue of Cell Metabolism, the study found that immune sensor Nlrp3 inflammasome is a common trigger of this inflammation-driven loss of function that manifests itself in insulin-resistance, bone loss, frailty, and cognitive decline in aging.
As the elderly population increases, clinicians are seeing a spike in age-related diseases, but scientists did not fully understand the role of inflammation. What is commonly known is that as we age, our cells change, leading the immune system to produce chronic, low-level inflammation throughout the body. Aging is also a major risk factor for multiple chronic diseases, but according to the researchers, biomedical enterprise spends billions of dollars to tackle each age-dependent disease separately.
"This is the first study to show that inflammation is causally linked to functional decline in aging," said lead author Vishwa Deep Dixit, professor of comparative medicine and immunobiology at Yale School of Medicine. "There are multiple cellular triggers of inflammation throughout the body, but we've pinpointed Nlrp3 as the specific sensor that activates inflammation with age."
"If aging is indeed a common factor for multiple diseases, the unanswered question is, can we identify the triggers of aging that cause low-level inflammation so that 'switching off' the trigger can slow the onset of multiple chronic diseases that are age-dependent at their onset," Dixit added. "Since aging affects us all, if this goal can be achieved, it is likely to significantly improve the healthspan and may also lower healthcare costs as the aging population increases in the U.S."
Dixit and his colleagues investigated the normal aging process of mice that were free of diseases, and fed a normal diet. The research team found that immune sensor Nlrp3 inflammasome is activated in response to aging. They then tested mice to determine if reducing the activity of Nlrp3 inflammasome lowers inflammation, and aging-associated decline in function. Results showed that animals with lower Nlrp3 activation were protected from many age-related disorders such as dementia, bone loss, glucose intolerance, cataracts, and thymus degeneration. Functionally, the mice also performed better, were less frail, and ran for longer durations. The researchers also tested another immune sensor called caspase11, which is activated in response to certain infections, and found that it was not linked to the age-related inflammation process.
"Now that we've identified this mechanism in the Nlrp3 sensor, we might be able to manipulate this immune sensor to delay, or reduce inflammation," Dixit said. "This could lead to the possibility of prolonging healthspan, potentially leading to an old age relatively free of disease or disability."
Dixit said additional studies are needed to explore whether the Nlrp3 mechanism can be safely manipulated without impairing the immune system. He points out that although there are several anti-inflammatory drugs available, none seem to be effective in expanding the healthspan. "One of our long-term goals is to develop therapies or specific diets that could dampen the excessive inflammation process as a means to prevent chronic diseases," he said.
###
Other authors on the study include Yun-Hee Youm, Ryan W. Grant, Laura R. McCabe, Diana C. Albarado, Kim Yen Nguyen, Anthony Ravussin, Paul Pistell, Susan Newman, Renee Carter, Amanda Lague, Heike Munzberg, Clifford J. Rosen, Donald K. Ingram, and J. Michael Salbaum.
The study was supported by the National Institutes of Health (AG043608, AI105097, and DK090556, P20RR02195, HD055528); The Genomics and Core CBB Core facilities supported by Pennington Center of Biomedical Research Excellence (NIH 8P20 GM 103528) and Nutrition and Obesity Research Center (NIH P30DK072476).
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Controlling the triggers of age-related inflammation could extend 'healthspan'
PUBLIC RELEASE DATE:
21-Oct-2013
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]
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Contact: Karen Peart karen.peart@yale.edu 203-432-1326 Yale University
Inflammation is the common denominator of many chronic age-related diseases such as arthritis, gout, Alzheimer's, and diabetes. But according to a Yale School of Medicine study, even in the absence of a disease, inflammation can lead to serious loss of function throughout the body, reducing healthspan that portion of our lives spent relatively free of serious illness and disability.
Published as the cover article in the October issue of Cell Metabolism, the study found that immune sensor Nlrp3 inflammasome is a common trigger of this inflammation-driven loss of function that manifests itself in insulin-resistance, bone loss, frailty, and cognitive decline in aging.
As the elderly population increases, clinicians are seeing a spike in age-related diseases, but scientists did not fully understand the role of inflammation. What is commonly known is that as we age, our cells change, leading the immune system to produce chronic, low-level inflammation throughout the body. Aging is also a major risk factor for multiple chronic diseases, but according to the researchers, biomedical enterprise spends billions of dollars to tackle each age-dependent disease separately.
"This is the first study to show that inflammation is causally linked to functional decline in aging," said lead author Vishwa Deep Dixit, professor of comparative medicine and immunobiology at Yale School of Medicine. "There are multiple cellular triggers of inflammation throughout the body, but we've pinpointed Nlrp3 as the specific sensor that activates inflammation with age."
"If aging is indeed a common factor for multiple diseases, the unanswered question is, can we identify the triggers of aging that cause low-level inflammation so that 'switching off' the trigger can slow the onset of multiple chronic diseases that are age-dependent at their onset," Dixit added. "Since aging affects us all, if this goal can be achieved, it is likely to significantly improve the healthspan and may also lower healthcare costs as the aging population increases in the U.S."
Dixit and his colleagues investigated the normal aging process of mice that were free of diseases, and fed a normal diet. The research team found that immune sensor Nlrp3 inflammasome is activated in response to aging. They then tested mice to determine if reducing the activity of Nlrp3 inflammasome lowers inflammation, and aging-associated decline in function. Results showed that animals with lower Nlrp3 activation were protected from many age-related disorders such as dementia, bone loss, glucose intolerance, cataracts, and thymus degeneration. Functionally, the mice also performed better, were less frail, and ran for longer durations. The researchers also tested another immune sensor called caspase11, which is activated in response to certain infections, and found that it was not linked to the age-related inflammation process.
"Now that we've identified this mechanism in the Nlrp3 sensor, we might be able to manipulate this immune sensor to delay, or reduce inflammation," Dixit said. "This could lead to the possibility of prolonging healthspan, potentially leading to an old age relatively free of disease or disability."
Dixit said additional studies are needed to explore whether the Nlrp3 mechanism can be safely manipulated without impairing the immune system. He points out that although there are several anti-inflammatory drugs available, none seem to be effective in expanding the healthspan. "One of our long-term goals is to develop therapies or specific diets that could dampen the excessive inflammation process as a means to prevent chronic diseases," he said.
###
Other authors on the study include Yun-Hee Youm, Ryan W. Grant, Laura R. McCabe, Diana C. Albarado, Kim Yen Nguyen, Anthony Ravussin, Paul Pistell, Susan Newman, Renee Carter, Amanda Lague, Heike Munzberg, Clifford J. Rosen, Donald K. Ingram, and J. Michael Salbaum.
The study was supported by the National Institutes of Health (AG043608, AI105097, and DK090556, P20RR02195, HD055528); The Genomics and Core CBB Core facilities supported by Pennington Center of Biomedical Research Excellence (NIH 8P20 GM 103528) and Nutrition and Obesity Research Center (NIH P30DK072476).
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Almost all patients suffering from head and neck squamous cell carcinoma (HNSCC) develop canker sores, a complication resulting from different modalities of treatment, namely stem cell transplantation, chemotherapy, and radiotherapy. Canker sore is divided in five grades (zero to four) by the World Health Organization (WHO), with severe cases (grades 3 and 4) being associated with pain, weight loss, poor quality of life, and higher hospital costs due to increased healthcare needs. Severe canker sore can also lead to treatment interruption, which may decrease the patient's chances of surviving the cancer.
No effective preventative strategy is currently available for canker sore, but prospective trials of low-level laser therapy (LLLT) done in HNSCC patients undergoing chemoradiotherapy showed promising results. However, additional trials detected a high incidence of canker sore among patients, leaving the question of whether LLLT can effectively prevent canker sore still open.
Now, a group of scientists led by Dr. Heliton Spindola Antunes at the National Cancer Institute (INCA) in Rio de Janeiro, Brazil, has successfully performed a definitive trial showing that LLLT reduces the occurrence of canker sore in HNSCC patients undergoing concurrent chemoradiotherapy and improves patient's quality of life.
The trial was performed with 94 HNSCC patients undergoing chemoradiotherapy. They were divided into two groups of 47 individuals, one of which received LLLT while the other received placebo. Researchers observed a significant difference in the incidence of canker sore grades 3 and 4 between groups. For instance, while in the group of patients receiving LLLT only three patients developed severe cases of canker sore, in the group receiving the placebo this number was 19. There were also significant differences in the absence of canker sore (grades 0-1), with the LLLT group having 59.6% of patients free of canker sore as opposed to 21.3% in the placebo group. The LLLT group had less severe oral pain and, as a result, used fewer opioid analgesics. They were also less likely to require gastrostomy (a surgical opening into the stomach for nutritional support) throughout the cancer treatment.
"For ethical reasons," says Dr Antunes, "all patients who developed canker sore grades 3 or 4 in the placebo arm were then offered the option of receiving LLLT. They all improved to grade 2 or lower, supporting the evidence that LLLT is an effective choice to prevent or treat canker sore in these patients."
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The article entitled "Phase III trial of low-level laser therapy to prevent oral mucositis in head and neck patients treated with concurrent chemoradiation" has been published ahead of print in Radiotherapy & Oncology and is available at http://dx.doi.org/10.1016/j.radonc.2013.08.010
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Almost all patients suffering from head and neck squamous cell carcinoma (HNSCC) develop canker sores, a complication resulting from different modalities of treatment, namely stem cell transplantation, chemotherapy, and radiotherapy. Canker sore is divided in five grades (zero to four) by the World Health Organization (WHO), with severe cases (grades 3 and 4) being associated with pain, weight loss, poor quality of life, and higher hospital costs due to increased healthcare needs. Severe canker sore can also lead to treatment interruption, which may decrease the patient's chances of surviving the cancer.
No effective preventative strategy is currently available for canker sore, but prospective trials of low-level laser therapy (LLLT) done in HNSCC patients undergoing chemoradiotherapy showed promising results. However, additional trials detected a high incidence of canker sore among patients, leaving the question of whether LLLT can effectively prevent canker sore still open.
Now, a group of scientists led by Dr. Heliton Spindola Antunes at the National Cancer Institute (INCA) in Rio de Janeiro, Brazil, has successfully performed a definitive trial showing that LLLT reduces the occurrence of canker sore in HNSCC patients undergoing concurrent chemoradiotherapy and improves patient's quality of life.
The trial was performed with 94 HNSCC patients undergoing chemoradiotherapy. They were divided into two groups of 47 individuals, one of which received LLLT while the other received placebo. Researchers observed a significant difference in the incidence of canker sore grades 3 and 4 between groups. For instance, while in the group of patients receiving LLLT only three patients developed severe cases of canker sore, in the group receiving the placebo this number was 19. There were also significant differences in the absence of canker sore (grades 0-1), with the LLLT group having 59.6% of patients free of canker sore as opposed to 21.3% in the placebo group. The LLLT group had less severe oral pain and, as a result, used fewer opioid analgesics. They were also less likely to require gastrostomy (a surgical opening into the stomach for nutritional support) throughout the cancer treatment.
"For ethical reasons," says Dr Antunes, "all patients who developed canker sore grades 3 or 4 in the placebo arm were then offered the option of receiving LLLT. They all improved to grade 2 or lower, supporting the evidence that LLLT is an effective choice to prevent or treat canker sore in these patients."
###
The article entitled "Phase III trial of low-level laser therapy to prevent oral mucositis in head and neck patients treated with concurrent chemoradiation" has been published ahead of print in Radiotherapy & Oncology and is available at http://dx.doi.org/10.1016/j.radonc.2013.08.010
[
| E-mail
Share
]
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.